Skip to main contentNews & ViewsPublished: 07 October 2025Animal biotechnologyBjörn Oback ORCID: orcid.org/0000-0001-7279-45651 Nature Biotechnology (2025)Cite this articleSubjectsCloningGenetic engineeringStem-cell biotechnologySpermatid-like haploid stem cells produce genome-edited farm animals in one generation.This is a preview of subscription content, access via your institutionAccess optionsAccess Nature and 54 other Nature Portfolio journalsGet Nature+, our best-value online-access subscription27,99 € / 30 dayscancel any timeLearn moreSubscribe to this journalReceive 12 print issues and online access269,00 € per yearonly 22,42 € per issueLearn moreBuy this articlePurchase on SpringerLinkInstant access to full article PDFBuy nowPrices may be subject to local taxes which are calculated during checkoutFig. 1: Generation of genome-edited livestock from spermatid-like haESCs.ReferencesYang, L. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-025-02832-4 (2025).Leeb, M. & Wutz, A. Nature 479, 131–134 (2011).Article CAS PubMed PubMed Central Google Scholar Elling, U. et al. Cell Stem Cell 9, 563–574 (2011).Article CAS PubMed PubMed Central Google Scholar Yi, M., Hong, N. & Hong, Y. Science 326, 430–433 (2009).Article CAS PubMed Google Scholar Yang, H. et al. Cell 149, 605–617 (2012).Article CAS PubMed Google Scholar Wan, H. et al. Cell Res. 23, 1330–1333 (2013).Article CAS PubMed PubMed Central Google Scholar Elling, U. et al. Nature 550, 114–118 (2017).Article CAS PubMed PubMed Central Google Scholar Smith, A. Development 144, 365–373 (2017).Article CAS PubMed PubMed Central Google Scholar Antony, J., Oback, F., Chamley, L. W., Oback, B. & Laible, G. Mol. Cell. Biol. 33, 974–983 (2013).Article CAS PubMed PubMed Central Google Scholar Czernik, M., Iuso, D., Toschi, P., Khochbin, S. & Loi, P. Nat. Protoc. 11, 2170–2188 (2016).Article CAS PubMed Google Scholar Download referencesAuthor informationAuthors and AffiliationsBioeconomy Science Institute, Nelson, New ZealandBjörn ObackAuthorsBjörn ObackView author publicationsSearch author on:PubMed Google ScholarCorresponding authorCorrespondence to Björn Oback.Ethics declarationsRights and permissionsReprints and permissionsAbout this article