The Kansas City Chiefs welcome the Detroit Lions to Arrowhead Stadium on Sunday night in one of the standout fixtures of this weekend’s NFL slate.Kansas City Chiefs v Detroit Lions best betsDetroit +2.5, 53+ points, Jared Goff 2+ passing touchdowns, Amon-Ra St Brown 71+ receiving yards at 6/1 with Paddy PowerKansas City Chiefs v Detroit latest oddsFind the latest Kansas City Chiefs v Detroit Lions moneyline betting odds here, odds courtesy of BetMGM and are subject to change.Kansas City Chiefs – 8/11Detroit Lions – 11/10Kansas City Chiefs v Detroit Lions predictionsThe Chiefs enter the primetime clash as narrow favourites against a formidable Detroit side, despite holding a 2–3 record heading into Week 6.Andy Reid’s team have featured in each of the last seven AFC Championship Games and five of the past six Super Bowls—including the last three—but began this season 0–2 for the first time in 11 years.Early losses to the LA Chargers in Brazil and the Philadelphia Eagles at home—a rematch of last season’s Super Bowl—had Kansas City fans fearing a rocky campaign. However, back-to-back wins over the New York Giants and Baltimore Ravens seemed to restore some momentum.That optimism took a hit last weekend, though, when the Chiefs suffered a shock defeat to the Jacksonville Jaguars. Now sitting below .500 nearly a third of the way through the season, Kansas City will be eager to get back on track under the lights this Sunday.The Detroit Lions, meanwhile, claimed the NFC’s top seed in last season’s playoffs before being upset at home by the Washington Commanders in the divisional round.An opening-night loss to the Green Bay Packers this season raised early doubts about Detroit’s credentials, but Dan Campbell’s side have since rattled off four straight wins to move into Week 6 with the joint-best record in the league.Victories over the Chicago Bears, Baltimore Ravens, Cleveland Browns, and most recently the Cincinnati Bengals have the Lions brimming with confidence ahead of their trip to Kansas City.The teams have faced off twice this decade—both meetings at Arrowhead—and both ended in narrow, one-point wins for Detroit, suggesting another tight and thrilling contest could be in store on Sunday night.A close and competitive game can be expected, with Detroit perhaps edging the contest given their momentum, perhaps a 30-27 win for the visitors.Kansas City Chiefs v Detroit Lions betting tipsGoff and St Brown to star as Lions go five in a rowDetroit head to Arrowhead with a four match winning streak, in which they’re averaging more than 40 points per game, while the 2-3 Kansas City Chiefs have looked far from their best this season.Jared Goff leads the NFL in touchdown passes with 12 in five games, while only four players have more receiving yeards than the Lions’ Amon-Ra St Brown, who’s averaging 84 yards per game at the moment.Detroit +2.5, 53+ points, Jared Goff 2+ passing touchdowns, Amon-Ra St Brown 71+ receiving yards at 6/1 with Paddy PowerHow to watch Kansas City Chiefs v Detroit LionsLocation: Arrowhead Stadium, Kansas CityDate and time: Monday 13th October 2025, 1:20amHow to watch: Sky Sports Main Event, Sky Sports NFL, Sky Sports Ultra HDRMore NFL predictionsFind more predictions and betting tips from our expert punters in our match previews on the NFL as well as other sports around the globeCommercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. GambleAware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.Free Bet OffersSee all the best free bets and betting offers available in the UK over at our dedicated pageSee all free bets18+ gambleaware.org. T&Cs apply