Skip to main contentNews & ViewsPublished: 07 October 2025Coronary artery diseaseStephen B. Montgomery ORCID: orcid.org/0000-0002-5200-39031,2,3 Nature Cardiovascular Research (2025)Cite this articleSubjectsCardiovascular geneticsGenomicsTranscriptional regulatory elementsMassively parallel reporter assays (MRPAs) are used in vascular smooth muscle cells to measure the functional effects of over 25,000 variants associated with coronary artery disease. This approach identifies regulatory variants in moderate linkage to disease-associated loci, implicating a broader spectrum of causal variants.This is a preview of subscription content, access via your institutionAccess optionsSubscribe to this journalReceive 12 digital issues and online access to articles118,99 € per yearonly 9,92 € per issueLearn moreBuy this articlePurchase on SpringerLinkInstant access to full article PDFBuy nowPrices may be subject to local taxes which are calculated during checkoutFig. 1: MPRA of moderately linked CAD GWAS variants identifies more causal effects.ReferencesSolomon, C. U. et al. Circulation 146, 917–929 (2022).Article CAS PubMed PubMed Central Google Scholar Liu, B. et al. Am. J. Hum. Genet. 103, 377–388 (2018).Article CAS PubMed PubMed Central Google Scholar Tewhey, R. et al. Cell 165, 1519–1529 (2016).Article CAS PubMed PubMed Central Google Scholar Deng, C. et al. Science 384, eadh0559 (2024).Article CAS PubMed PubMed Central Google Scholar Kellman, L. N. et al. Nat. Genet. 57, 718–728 (2025).Article CAS PubMed Google Scholar Toropainen, A. et al. Genome Res. 32, 409–424 (2022).Article CAS PubMed PubMed Central Google Scholar Barbera, N. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-025-00714-1 (2025).Article Google Scholar Gomez, D. & Owens, G. K. Cardiovasc. Res. 95, 156–164 (2012).Article CAS PubMed PubMed Central Google Scholar Download referencesAcknowledgementsS.B.M. is funded by grants from the National Institutes of Health (NIH; R03OD039976, R01MH125244, U01AG072573 and U01HG012069).Author informationAuthors and AffiliationsDepartment of Pathology, Stanford University, Stanford, CA, USAStephen B. MontgomeryDepartment of Genetics, Stanford University, Stanford, CA, USAStephen B. MontgomeryDepartment of Biomedical Data Science, Stanford University, Stanford, CA, USAStephen B. MontgomeryAuthorsStephen B. MontgomeryView author publicationsSearch author on:PubMed Google ScholarCorresponding authorCorrespondence to Stephen B. Montgomery.Ethics declarationsRights and permissionsReprints and permissionsAbout this article