$ANNX – Massive Breakout! Former Downtrend Broken With Eyes on $Annexon, Inc.BATS:ANNXMyMIWalletANNX just printed one of its strongest breakout candles of 2025 — surging from the $3s into the $4.00+ range on explosive volume. This move breaks a multi-month descending structure that has held Annexon down since late 2023, officially flipping the market structure bullish. After over a year of accumulation between $2.00–$3.25, ANNX is now targeting higher levels as buyers step in aggressively across all timeframes. 📊 Technical Overview Support Levels: $3.55 → $3.25 → $2.75 Resistance Levels: $4.12 → $5.00 → $5.50 Structure: Higher-high + breakout above Ichimoku cloud + full downtrend violation Momentum: RSI ripping into bullish expansion; volume at multi-month highs Trend Bias: Strongly bullish above $3.55 A clean continuation above $4.12 confirms the breakout and opens the path toward the $5.00–$5.50 prior supply zone. If buyers maintain control, this could be the first leg of a larger biotech momentum sequence. 🧪 Sector Context Annexon (ANNX) operates in the neuro-immunology biotech space — a sector known for abrupt trend changes following clinical updates, FDA milestones, or institutional rotations. Small-cap biotech names across the board (TCRT, SANA, VCNX, MRSN) have shown renewed momentum this quarter, signaling a potential sector rotation into undervalued clinical-stage companies. ANNX spent over 12 months building a base — moves like today typically occur before catalysts become public. 💡 My Plan Entry Zone: $3.60–$3.85 on pullbacks Targets: $4.50 → $5.00 → $5.50 Stretch Target: $7.85 (measured move from macro range breakout) Invalidation: Close below $3.25 = failed breakout → back to accumulation range The ideal scenario is a small pullback into the 8EMA / 20EMA on the daily chart before the next leg up. ANNX just broke a year-long downtrend with huge volume — the big question now is: Does it push into the $5.00–$5.50 zone next, or does it consolidate first? Drop your thoughts ⬇️ I’ll post the continuation update if ANNX clears $4.12 with strength 📈 XBI TCRT VCNX MRSN