Skip to main contentNews & ViewsPublished: 23 September 2025AntimicrobialsRafael Laso-Pérez ORCID: orcid.org/0000-0002-6912-78651 Nature Microbiology (2025)Cite this articleSubjectsAntimicrobialsArchaeaData miningDrug discoveryA deep-learning algorithm unravels a collection of archaeasins, peptides from the archaeal proteome with potential antimicrobial activity and implications for the development of next-generation antibioticsThis is a preview of subscription content, access via your institutionAccess optionsAccess Nature and 54 other Nature Portfolio journalsGet Nature+, our best-value online-access subscription27,99 € / 30 dayscancel any timeLearn moreSubscribe to this journalReceive 12 digital issues and online access to articles118,99 € per yearonly 9,92 € per issueLearn moreBuy this articlePurchase on SpringerLinkInstant access to full article PDFBuy nowPrices may be subject to local taxes which are calculated during checkoutFig. 1: Discovery of potential antimicrobial EPs from the archaeal proteome.ReferencesAntimicrobial Resistance Collaborators. Lancet 399, 629–655 (2022).Article Google Scholar Hutchings, M. I., Truman, A. W. & Wilkinson, B. Curr. Opin. Microbiol. 51, 72–80 (2019).Article CAS PubMed Google Scholar Torres, M. D. T. et al. Nat. Biomed. Eng. 6, 67–75 (2022).Article PubMed Google Scholar Meisel, H. Curr. Med. Chem. 12, 1905–1919 (2005).Article CAS PubMed Google Scholar Bruni, N. et al. Molecules 21, 752 (2016).Article PubMed PubMed Central Google Scholar Torres, M. D. T., Wan, F. & de la Fuente-Nunez, C. Nat. Microbiol. https://doi.org/10.1038/s41564-025-02061-0 (2025).Article PubMed PubMed Central Google Scholar Wan, F., Torres, M. D. T., Peng, J. & de la Fuente-Nunez, C. Nat. Biomed. Eng. 8, 854–871 (2024).Article CAS PubMed PubMed Central Google Scholar Jangra, M. et al. Nature 640, 1022–1030 (2025).Article CAS PubMed Google Scholar Brock, T. D. & Freeze, H. J. Bacteriol. 98, 289–297 (1969).Article CAS PubMed PubMed Central Google Scholar Staley, J. T. & Konopka, A. Annu. Rev. Microbiol. 39, 321–346 (1985).Article CAS PubMed Google Scholar Download referencesAuthor informationAuthors and AffiliationsDepartment of Biogeochemistry and Microbial Ecology, Museo Nacional de Ciencias Naturales, CSIC, Madrid, SpainRafael Laso-PérezAuthorsRafael Laso-PérezView author publicationsSearch author on:PubMed Google ScholarCorresponding authorCorrespondence to Rafael Laso-Pérez.Ethics declarationsRights and permissionsReprints and permissionsAbout this article