The cryptocurrency market has just received a significant vote of confidence from Wall Street. Nasdaq, one of the world’s most powerful stock exchanges, has invested $50 million into Gemini during the exchange’s IPO. The move is more than just a financial bet; it signals the merging of traditional finance with crypto infrastructure. This development sets the stage for a new wave of institutional adoption among investors seeking the best cryptos to invest in at present. Three tokens, Little Pepe (LILPEPE), Ethereum (ETH), and Ondo Finance (ONDO), stand out as the top watch amidst this dynamic.Nasdaq’s $50M Bet on Gemini: What It Means for CryptoNasdaq’s stake in Gemini is about more than IPO participation. It’s a strategic partnership that integrates Gemini’s custody and staking services with Nasdaq’s extensive trading platforms. In return, Gemini’s institutional clients gain access to Nasdaq’s Calypso collateral management system.This signals two significant shifts:Tokenization is going mainstream. Nasdaq recently revealed plans to list tokenized securities, essentially blockchain-based versions of traditional stocks. This aligns perfectly with Gemini’s European tokenized stock offerings.Institutional-grade custody and staking are being normalized. By leaning on Gemini, Nasdaq conveys that crypto infrastructure is ready for Wall Street scale.This bridge between TradFi and DeFi could fuel the next bull market for retail and institutional investors.Little Pepe (LILPEPE): The Meme Coin With UtilityAmong the best cryptos to invest in, Little Pepe is gaining traction for being more than a meme. This project is rewriting the memecoin narrative by launching the world’s first Layer 2 blockchain designed exclusively for memes. Instead of being just a viral token, LILPEPE is creating a scalable ecosystem with near-zero gas fees, lightning-fast finality, and sniper-bot resistance to protect retail investors. The presale has already turned heads, raising over $25 million and selling over 15.7 billion tokens. Each token at Stage 13 goes for $0.0022, up from $0.001 in Stage 1. Early buyers have doubled their money, and momentum is strong. What sets Little Pepe apart is its community-first approach. A strict vesting schedule, a completed CertiK audit, and two top-tier CEX listings secured for launch all point to a project built for long-term sustainability. Add the mega giveaways worth over 15 ETH and a dedicated meme Launchpad called PEPE’s Pump Pad, and LILPEPE has the hype and infrastructure to lead the next crypto bull cycle.Ethereum (ETH): Institutional Darling With Supply ShockEthereum remains a cornerstone for crypto investors. Its role as the backbone of DeFi, NFTs, and tokenization makes it a clear beneficiary of Nasdaq’s push into blockchain services. Ethereum’s ETF inflows have now surpassed $27 billion, locking up supply while demand surges. At the same time, 30% of ETH is staked, reducing available liquidity. This supply shock and institutional flows have helped ETH climb above $4,400.Ethereum Price Chart | Source: CoinGeckoThe recent Pectra upgrade introduced new scaling and staking efficiencies, further boosting adoption. Analysts from digital asset bank Sygnum say Ethereum’s valuation is now entering a “perfect storm” of fundamentals and regulation. For long-term investors, ETH remains one of the best cryptos to invest in, as it solidifies itself as core digital infrastructure.Ondo Finance (ONDO): Tokenized Treasuries PowerhouseOndo Finance is carving out a unique niche in real-world asset (RWA) tokenization, and Nasdaq’s focus on tokenized securities puts ONDO directly in the spotlight. In the past week, Ondo Global Markets surpassed $100 million TVL, and its total value locked hit $1.5 billion, nearly triple its January levels. Partnerships with Fidelity, BlackRock, and WisdomTree demonstrate that Wall Street is already investing in ONDO’s ecosystem.ONDO Price Chart | Source: CoinGeckoONDO’s native token surged to a high of $1.06 this week, breaking multi-month resistance. With every uptick in RWA adoption, more value flows into the protocol, supporting price action. While future unlocks in 2026 pose long-term risks, the short-term trend favors growth as tokenized treasuries become one of the hottest narratives in crypto.Aligning With Wall Street’s New PlayNasdaq’s $50M Gemini bet is more than symbolic. It shows that legacy finance is not just flirting with crypto, but actively integrating it. For investors, the opportunity lies in backing tokens that align with this institutional shift, while offering high growth potential.Little Pepe delivers viral meme appeal with real utility and massive presale momentum.Ethereum stands as the backbone of tokenization and institutional adoption.Ondo Finance offers direct exposure to the rapidly growing RWA market.These three make a strong case as the best cryptos to invest in this September. However, the asymmetric upside lies with Little Pepe: it is early, has momentum, is anticipating CEX listings, and is launching a new phase of the meme economy. Join the Little Pepe presale here before the next price jump.For more information about Little Pepe (LILPEPE) visit the links below:Website: https://littlepepe.comWhitepaper: https://littlepepe.com/whitepaper.pdfTelegram: https://t.me/littlepepetokenTwitter/X: https://x.com/littlepepetokenThe post 3 Best Cryptos to Invest in as Nasdaq Makes Huge Move with $50M Investment in Gemini appeared first on Blockonomi.