The Kansas City Chiefs travel to Florida tonight to face the Jacksonville Jaguars in the final matchup of the NFL weekend.Jacksonville Jaguars v Kansas City Chiefs best betsKansas City -3.5, Patrick Mahomes over 22.5 rushing yards, Travis Etienne touchdown, over 45.5 points at 21/2 with BetMGMJacksonville Jaguars v Kansas City Chiefs latest oddsFind the latest Jacksonville Jaguars v Kansas City Chiefs moneyline betting odds here, odds courtesy of BetMGM and are subject to change.Jacksonville Jaguars – 33/20Kansas City Chiefs – 1/2Jacksonville Jaguars v Kansas City Chiefs predictionsThe Chiefs enter this Monday night clash aiming to make it three straight wins as they continue to recover from a rocky start that saw them open the season with back-to-back defeats.Under Andy Reid, Kansas City have reached seven consecutive AFC Championship Games and five of the last six Super Bowls—winning three—but their 0-2 start marked their worst opening to a season in 11 years.Losses to the LA Chargers in Sao Paulo and the defending champions, the Philadelphia Eagles, at Arrowhead left the Chiefs looking uncharacteristically fragile. However, consecutive victories over the New York Giants and a resurgent performance against the Baltimore Ravens have put them back on track.A win tonight at EverBank Stadium would see Patrick Mahomes and his teammates draw level at the top of the AFC West alongside the Chargers and Denver Broncos.The Jaguars, meanwhile, have made a strong start to their campaign. They come into this home fixture with a 3-1 record and riding a two-game winning streak.New head coach Liam Coen has impressed in his debut NFL head coaching role after serving as offensive coordinator for the Tampa Bay Buccaneers last season. His tenure began with a comfortable home victory over the Carolina Panthers.A setback followed against the Cincinnati Bengals, but Jacksonville responded with back-to-back wins over the Houston Texans and San Francisco 49ers. Another victory tonight would move them to 4-1 and give them a share of the league’s best record.Kansas City have dominated this matchup in recent years, winning eight of the last nine meetings with Jacksonville since 2010. However, the Jaguars did come out on top the last time the sides met, claiming a 26-13 home victory in August last year.I expect the Chiefs to continue their winning streak tonight and return to Missouri with the victory in a tightly contested affair, winning 27-21.Jacksonville Jaguars v Kansas City Chiefs betting tipsAllen to star in big Bills winThe Chiefs appear to finally have found their feet this season after a slow start but last weekend’s win over Baltimore suggests they’re back to being close to the team that have reached the last seven AFC Championship.sPatrick Mahomes is upped his rushing this season with 130 yards and two rushing touchdowns in his four matches this season, while for the Jaguars, running back Travis Etienne leads their scoring charts and will be called upon frequently in the biggest game of their season.Kansas City -3.5, Patrick Mahomes over 22.5 rushing yards, Travis Etienne touchdown, over 45.5 points at 21/2 with BetMGMHow to watch Jacksonville Jaguars v Kansas City ChiefsLocation: EverBank Stadium, Jacksonville, FloridaDate and time: Tuesday 7th October 2025, 1:15amHow to watch: Sky Sports Main Event, Sky Sports NFL, Sky Sports Ultra HDRMore NFL predictionsFind more predictions and betting tips from our expert punters in our match previews on the NFL as well as other sports around the globeCommercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. GambleAware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.Free Bet OffersSee all the best free bets and betting offers available in the UK over at our dedicated pageSee all free bets18+ gambleaware.org. T&Cs apply