The major indices close higher for the second of three days this week. The gains were led by the NASDAQ index which rose by 1.29%. The S&P index rose by 0.78%, and the Dow Industrial Average rose 0.49%.With the week now half over, the S&P index is down -0.14%, the NASDAQ index is up 0.61%, and the Dow Industrial Average is down -0.49%.Some winners today include:Biotechnology / HealthcareModerna: +16.07%Artificial Intelligence / Cloud InfrastructureNebius NV: +12.65%Crypto / Digital Asset ExposureStrategy: +10.36%Robinhood Markets: +8.07%Bitcoin Futures: +7.43%BTCUSD: +7.39%Grayscale Bitcoin (BTC): +7.14%Software / Cloud ServicesBox Inc: +9.95%Shopify Inc: +6.34%Zoom Video: +6.15%CrowdStrike Holdings: +4.16%Palantir: +4.00%Semiconductors / Hardware / AI InfrastructureSuper Micro Computer: +6.42%AMD: +5.82%Intel: +5.73%Micron: +5.52%Western Digital: +4.16%RetailMacy’s Inc: +5.03%Looking at the losers:Consumer / Retail / FoodChewy: -4.06%Papa John's: -3.69%Celsius: -3.27%General Mills: -2.20%Media / EntertainmentParamount Skydance: -3.21%Live Nation Entertainment: -2.12%Airlines / TravelAlaska Air: -2.87%United Airlines Holdings: -1.99%Energy / Oil ServicesBaker Hughes: -2.69%Exxon Mobil: -2.17%Healthcare / Medical DevicesBoston Scientific: -2.26%Technology / MaterialsCorning: -1.91% This article was written by Greg Michalowski at investinglive.com.