Arsenal are expected to ring the changes for Wednesday night’s clash at Port Vale – and could make as many as ten alterations.The Gunners will be looking to flex their immense squad depth as they get their Carabao Cup campaign underway at Vale Park – live on talkSPORT.Arteta could field a completely different team to the one that drew 1-1 against Manchester CityAFPIt’s a competition the north London giants have not won since beating Sheffield Wednesday in the 1993 final.And boss Mikel Arteta will be hoping for a return to winning ways following Sunday’s 1-1 draw against Premier League title rivals Manchester City.Arteta angered fans with his team selection against the Citizens, opting for a seemingly cautious and defensive-minded team.Eberechi Eze, Gabriel Martinelli and Ethan Nwaneri were all left out of the line-up despite being fully fit – resulting in a lack of creativity in the final third. It was Eze and Martinelli who combined for Arsenal‘s equaliser in the third minute of second half stoppage time to show Arteta why they should be starting.You can be sure the trio will all be named in his XI against the League One side where Arteta will be instructing his team to show no mercy.Arsenal are yet to lose to a lower league opposition in the Carabao Cup under the Spaniard’s tutelage.The last time Arsenal crashed out against a non-Premier League side was in 2015, with Championship side Sheffield Wednesday beating Arsene Wenger’s youthful side 3-0.Arteta is likely to mix youth with experience against Port Vale, while keeping a close eye on Sunday’s crunch match at Newcastle on Sunday.And after a summer in which Arsenal spent around £276.2million [including add-ons] on new signings, a host of new recruits will all be given a chance to shine in Staffordshire.Martinelli came off the bench to salvage a point for the Gunners against the CitizensGettyAfter two goals in as many games, he could now be recalled to the starting XI at Port ValeGettyHere talkSPORT.com takes a look at how Arsenal could start which sees ten changes and 11 tactical tweaks.How could Arsenal start against Port Vale?Goalkeeper Kepa Arrizabalaga is in line to make his Arsenal debut following his £5m switch from Chelsea.The 30-year-old was brought in to be David Raya’s back-up, with his Spanish compatriot so far starting all six matches this term.Moving to right-back, and Ben White is likely to come in for Jurrien Timber in what will be the England international’s first outing since the opening day victory over Manchester United.Myles Lewis-Skelly meanwhile seems nailed-on to come in at left-back for his first start of the season.A breakthrough 2024/25 campaign saw the 18-year-old come into the Three Lions set-up, but he has been limited to just 66 minutes of action due to Riccardo Calafiori’s strong showings.Lewis-Skelly has been named on the bench in each of Arsenal’s six matches so farGettyArteta is likely to shuffle it up in the heart of defence too, which could see the preferred centre-back pairing of William Saliba and Gabriel Magalhaes given a rest.Cristhian Mosquera will be recalled to the starting XI having impressed in Saliba’s absence.And he could play alongside Piero Hincapie, with the defender on loan from Bayer Leverkusen to make his first start in English football.Hincapie, who featured late on off the bench in last week’s Champions League win at Athletic Bilbao, was left out of the squad that faced City.It remains unclear why the Ecuadorian was omitted, with Arteta failing to state whether it will mean he misses Port Vale.Gooners are also in store for a new-look midfield trio with Christian Norgaard likely to replace Martin Zubimendi in the No.6 role.Norgaard and Hincapie are in line for their first Arsenal starts following their summer movesGettyFresh from his dazzling display against City, Eze could be given his first start in the middle of the pitch.He could feature as one of two roaming No.8s alongside Nwaneri.And Bukayo Saka could be set for an immediate return to the line-up following his second half substitute outing against Pep Guardiola’s men.The right winger, who has been battling a hamstring issue, replaced Noni Madueke at half-time.While Arteta may have wanted to manage Saka’s fitness, he may have no choice with Madueke going injured due to a knee knock.Madueke appears set to miss the next month of action in a blow for Arsenal, who are already without skipper Martin Odegaard, Kai Havertz and Gabriel Jesus.Saka will be keen for more minutes in the bank as he looks to return to full fitnessGettyArteta is also likely to recall Martinelli back to his line-up following two man of the match performances off the bench.Martinelli scored within 36 seconds after coming against Bilbao, before setting up Leandro Trossard to seal a 2-0 win.And after grabbing the equaliser against City, the Brazilian could now slot in down the left channel once again.Arsenal could also see a change up top to give Viktor Gyokeres a rest ahead of the weekend’s trip to Tyneside.This could see Trossard lead the line – moved from the left wing position he started at against City.The Belgian has often been deployed in a false No.9 role since joining from Brighton in January 2023, and would give the 30-year-old more game time having started just once this term.This could be how Arsenal start against Port Vale for their Carabao Cup tie