Arne Slot declared it would be a “completely changed lineup” against Southampton in the Carabao Cup, and he has delivered with 11 changes.After three games in seven days, which saw Slot make an average of only 2.3 changes, it is time to inject fresh legs for the Carabao Cup match against Championship opposition.Six first-team regulars have been given the night off, including Virgil van Dijk, Ryan Gravenberch and Mohamed Salah, with this a night for Liverpool’s squad depth to take centre stage.Giorgi Mamardashvili and Giovanni Leoni make their competitive debut, with Jeremie Frimpong, Joe Gomez and Andy Robertson completing the backline.Wataru Endo is named for his first start of the season, with Curtis Jones and Trey Nyoni joining the Japanese in midfield.As for the forward line, Alexander Isak will be hopeful of scoring his first goal for the club with Federico Chiesa and Rio Ngumoha lining up alongside the Swede.Slot has given the majority of his regular players the night off, but Milos Kerkez, Conor Bradley and Hugo Ekitike are among the senior options on the bench, as are youngsters Kieran Morrison, Kaide Gordon and Jayden Danns.Liverpool: Mamardashvili; Frimpong, Gomez, Leoni, Robertson; Endo, Jones; Chiesa, Nyoni, Ngumoha; IsakSubstitutes: Woodman, Kerkez, Bradley, Williams, Pilling, Morrison, Gordon, Danns, EkitikeSouthampton: McCarthy; Jelert, Edwards, Wood, Quarshie, Manning, Downes, Jander, Armstrong, Scienza, ArcherSubstitutes: Long, Harwood-Bellis, Charles, Matsuki, Fraser, Fellows, Robinson, Stewart, Downs5th different manager in 5 visitsSouthampton are Liverpool’s third round opponents in the Carabao Cup, and the Saints arrive at Anfield with a different manager at the helm for a fifth consecutive match.Since November 2021, the Saint have played at Anfield four times, each time with a different coach – Ivan Juric, Russell Martin, Nathan Jones, Ralph Hasenhuttl.Will Still is in the dugout this time around, and ex-Red Adam Lallana is part of his coaching staff.