Napoli have come flying out of the traps at the start of the Serie A season, winning each of their first four matches to set the pace in Italy’s top tier. But Antonio Conte’s team will be tested by Milan this weekend.Will the hosts come out on top at San Siro this weekend, or can Napoli march on and collect another three points?Back Napoli to beat Milan – 41/20 with BetMGMGo for a draw at half-time – 21/20 with BetfredTip Rasmus Hojlund to score any time – 11/4 with bet365Milan vs NapoliFind the latest Milan vs Napoli betting odds here. All odds are provided by our recommended football bookmakers and are subject to change. Stay in-play between matches with bet365’s live casino! Milan vs Napoli predictionsNapoli have had the perfect start to the Serie A season. Their record of four wins in four games has seen Antonio Conte’s side justify their status as title favourites.Napoli only just edged out Inter in a two-way tussle for the scudetto in 2024/25. The race was decided on the final day, when Napoli beat Cagliari 2-0 to finish a point clear of the Nerazzurri.Despite rumours that Conte could depart after Napoli’s triumph, the former Chelsea and Tottenham Hotspur head coach decided to stay put after discussions with the owner Aurelio De Laurentiis.That gives Napoli a sense of continuity that is not present at most of the other big teams in the division. Milan, Inter, Fiorentina, Roma, Lazio and Atalanta are all under new management. Juventus are not, but Igor Tudor only took charge in March. Napoli should benefit from the stability that others lack.On the other hand, the Partenopei are now having to balance domestic and continental commitments. They were entirely absent from European competition last season, giving Conte a full week to prepare for most matches. That was a huge advantage. This time around, Napoli will be more stretched.Conte’s charges lost 2-0 to Manchester City in their first Champions League match, but they boast a 100 percent record domestically following victories over Sassuolo (2-0), Cagliari (1-0), Fiorentina (3-1) and Pisa (3-2). However, after that defeat of Pisa Conte admitted his team are still getting used to the delicate balancing act.“When I say calm and preach caution, I mean it for this reason,” he said. “We, unlike others, don’t have a well-oiled squad to play a season with various commitments like the Champions League, Coppa Italia and Supercoppa.“Players come from different backgrounds and have the scudetto on their shirts: you play with high expectations. We, unlike others, have to work on the pitch to grow and level up, but sometimes you don’t have time and experience is gained slowly.”Conte was no doubt seeking to play down expectations, but Napoli now have a target on their backs as the defending champions.Milan will be aiming to shoot them down this weekend. Having won three of their first four games under the returning Max Allegri, the Rossoneri will give Napoli a good game on Sunday.Milan vs Napoli betting tips. 18+ GambleAware.org – Please play responsibly.Milan vs NapoliMilan and Napoli will do battle at San Siro in the standout fixture of the Serie A weekend.Napoli to edge this oneMilan reappointed Allegri over the summer, bringing back a manager who won the title with the club in 2011.Allegri also scooped five scudetti with Juventus, so he is not short of trophy-winning experience. Yet on Sunday he will be facing one of the best coaches in the world in the form of Conte.Napoli have not been perfect so far this season, and they are certainly not invincible. Yet they know what it takes to get over the line in big games like this one.Every Napoli player knows what is expected of him, whereas the Milan squad is still getting used to Allegri’s demands.There is unlikely to be much between the two sides, but Napoli can edge Sunday’s showdown at San Siro. Back Napoli to beat Milan at 41/20 with BetMGM Expect a tight first halfJuventus went in a very different direction after Allegri’s exit in 2024, but they arguably went backwards under Thiago Motta.Even so, the time had come for Juve to move on. Many fans had long since tired of Allegri’s tendency towards tactical caution.We will have to see if that becomes an issue at Milan further down the line, but this weekend the focus will be on making life difficult for Napoli first and foremost.Both teams will feel their way into this game, which looks set to be a slow-burner. We anticipate Milan and Napoli going in level at the break. Go for a draw at half-time at 21/20 with BetfredHojlund can strike againNapoli struck a deal to sign Rasmus Hojlund on loan from Manchester United at the end of the transfer window.The former Atalanta frontman has started each of Napoli’s last three matches in all competitions, so he should be in the XI again this weekend.Hojlund opened his account for his new club in the 3-1 victory over Fiorentina, and he has looked lively since then too.Things did not work out for the 22-year-old at Old Trafford, but he has settled in well at Napoli. Do not be surprised if he gets his name on the scoresheet at San Siro. Rasmus Hojlund to score any time at 11/4 with bet365 About the authorGreg LeaGreg Lea is a freelance football writer from London. He predominantly covers the Premier League and has had work published by the Guardian, FourFourTwo, ESPN and others.Follow Greg on X: @GregLeaFootballMilan vs Napoli predicted lineupsMilan expected lineup: Terracciano; Tomori, Gabbia, Pavlovic; Saelemaekers, Fofana, Modric, Rabiot, Estupinan; Pulisic, Gimenez.Napoli expected lineup: Meret; Di Lorenzo, Beukema, Buongiorno, Spinazzola; Gilmour; Politano, De Bruyne, Elmas, McTominay; Hojlund. Where to watch Milan vs NapoliLocation: San Siro, Milan, Italy.Date and time: Sunday 28th September, 7.45pm.How to watch: TNT Sports 1, DAZN.More Serie A predictionsWe have plenty more Serie A predictions and picks – find our latest betting tips from expert punters in our match preview overview.Commercial content notice: Taking one of the bookmaker offers featured in this article may result in a payment to talkSPORT. 18+. T&Cs apply. GambleAware.orgRemember to gamble responsiblyA responsible gambler is someone who:Establishes time and monetary limits before playingOnly gambles with money they can afford to loseNever chase their lossesDoesn’t gamble if they’re upset, angry or depressedGamcare – www.gamcare.org.ukGambleAware – www.gambleaware.orgFind our detailed guide on responsible gambling practices here.For help with a gambling problem, call the National Gambling Helpline on 0808 8020 133 or go to www.gamstop.co.uk to be excluded from all UK-regulated gambling websites.Most read in BettingMainz vs Borussia Dortmund predictions and betting tipsNottm Forest vs Sunderland predictions and betting tips - Can Isidor score another goal?Leeds vs Bournemouth predictions and betting tips - Can Semenyo score again?Tottenham vs Wolves predictions and betting tips - Bets on Richarlison, Kudus & RomeroBrentford vs Manchester United predictions and betting tipsCrystal Palace vs Liverpool predictions and betting tips - Unbeaten records on the line